Genetic Polymorphisms, Obesity, and the Relentless Battle Against Weight Regain: A Comprehensive Review.
British Journal of Nutrition (2020), 124, 809–823
Obesity is a significant health issue, increasing the risk of numerous chronic diseases such as metabolic syndrome, heart disease, obstructive sleep apnea, cancer, depression, and infertility ( 1 ) .
In this article, we delve into the fascinating world of genetic polymorphisms and their role in weight regain, a critical issue for those struggling with obesity and weight loss.
To ensure we uncover the most recent insights, our team conducted an extensive literature search using PubMed, a comprehensive database, spanning from its inception up until April 2020.
In the realm of weight management, understanding the role of nutrient metabolism - related genes is crucial in combating obesity and preventing weight regain.
A significant finding reveals that the levels of specific nutrient - associated metabolites in plasma vary significantly between lean individuals and those struggling with obesity.
These metabolites encompass branched - chain amino acids, aromatic amino acids, NEFA (Non - Esoteric Fatty Acids), and intermediates of fatty acid oxidation and branched - chain amino acid catabolism(16 ) .
It's fascinating to learn about the genetic factors that influence weight loss and obesity, particularly when it comes to weight regain.
A variety of genes, such as perilipin (PLIN), brain-derived neurotrophic factor (BDNF), leptin, PPARγ2, protein phosphatase Mg2+/Mn2+ dependent 1K (PPM1K), β-2 adrenergic receptor (ADRB2), IL-6 and glucocorticoid receptor (GRL), have been linked to weight regain.
For instance, PLIN coats intracellular lipid droplets and regulates adipocyte lipolysis.
If you're battling weight regain after a successful weight loss journey, you might want to pay attention to your genes!
Various genetic polymorphisms, or variations in your DNA, have been linked to the ability to maintain that hard - earned weight loss.
Let's take a look at some of these obesity - related genes and their connection with weight regain
Adipocytes are the key players in regulating body weight, and obesity, characterized by excessive adipose tissue, is a condition that affects millions worldwide(77).
It seems that our genetic makeup might play a significant role in our struggles with weight loss, particularly when it comes to obesity .
A growing body of research suggests that certain genetic polymorphisms are linked to the regain of weight after successful weight loss .